You must fill up the 3 urns at the top of the screen by making matches of the appropriate color. Trick is, you have to do them in the order they tell you - getting green matches when you need red matches does you no good!
So pay close attention to which color you are working on next.
Let's Twist Again:
You must, must, must rotate the board in order to play! Otherwise the pieces will get stacked up and you will lose. Use the arrow keys or click on the rotate arrows underneath the game board to rotate left or right.